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This effect could be replicated by a TRPC1/TRPC4/TRPC5 pan-inhibitor, HC-070, which implies a therapeutic potential to treat anxiety disorders (Just et al., 2018)
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Ann N Y Acad Sci 1216:8698
Recent advances in computational biology, particularly through the development of AlphaFold, have enabled the prediction of the structures of 98% of the human proteome 13,14
