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Ma Y, Li X, Zhang W, Ying X, Stien D (2021) A trace alkaloid, oleraisoindole A from Portulaca oleracea L

*In a clinical study of 32 women

The copper coordination also contributes to GHK-Cus antioxidant properties through SOD-mimetic activity and Nrf2 pathway activation

Modulation of longevity-associated genes by estrogens or phytoestrogens

ROS/RNS modulate the activity of a variety of transcription factors, including Apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref1), Hypoxia-Inducible Factor (HIF1), Activator protein 1 (AP1), nuclear factor erythroid 2related factor 2 (Nrf2), Nuclear factor-kappa B (NFB), p53 gene, forkhead box transcription factors (FOXO), and catenin (57)