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DNA methylation patterns can vary across different tissues and cell types, making it necessary to obtain samples from the disease-affected tissue for accurate analysis

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If mitochondrial iron overload is a prominent feature of the disease, the activities of FeS proteins, such as mitochondrial aconitase and succinate dehydrogenase, should be measured to evaluate whether FeS cluster biogenesis is impaired

Nox2 knockout (KO) mice (B6.129S- Cybb tm1Din /J) and age-matched C57Bl/6J mice, with Nox2 WT expression, were a gift from Tammy Kielian (University of Nebraska Medical Center;UNMC)

For the remaining 3 cases no details were reported [42, 43, 46]

NA, not available