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88 In cancer cells, by generating ROS, PRODH may trigger apoptosis and suppress mitogenic pathways (e.g

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The exogenous ROS burden creates an oxidatively stressed environment mainly by generating intracellular H 2 O 2 , which acts as a second messenger in cell signalling pathways

Biochim Biophys Acta 1830:31433153 Makar TK, Nedergaard M, Preuss A, Gelbard AS, Perumal AS, Cooper AJ (1994) Vitamin E, ascorbate, glutathione, glutathione disulfide, and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: evidence that astrocytes play an important role in antioxidative processes in the brain

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( 2 O 2 accumulation in the apoplast similar to action of NADPH oxidase, (3) the involvement of DHA in signaling events, and (4) possible involvement of (APX) in the apoplast