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Researchers are attempting to address this challenge through epigenetic mechanisms

72 , 73 The risk escalates to nearly 12-fold in individuals harboring all four risk alleles (GSTM1 active, GSTT1 null, GSTP1 Val rs1695, or GSTP1 Val rs1138272)

Sadybekov et al., 2020)

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Glutathione degradation by the alternative pathway (DUG pathway) in Saccharomyces cerevisiae is initiated by (Dug2p-Dug3p) 2 complex a novel glutamine amidotransferase (GATase) enzyme acting on glutathione

doi: 10.4161/psb.25504 35 HalliwellB.GutteridgeJ