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For instance, immune cells deploy a potent radical-to-non-radical oxidant cascade (O 2 H 2 O 2 HOCl/ONOO ) for host defense, while generic cellular homeostasis relies on non-radical H 2 O 2 to fine-tune kinase/phosphatase networks governing growth and adaptation [1113]

Dietary fiber may benefit chondrocyte activity maintenance

Carotenoids are provitamins (i.e., precursors of vitamin A) produced by plants that can be converted into retinal by the human body

demonstrated that JNK/c-Jun pathway activation can induce the expression of DKK1, thus inhibiting the canonical Wnt pathway

Mitochondrial-derived zinc accumulation can impair mitochondrial structure and function, negatively impacting animal development and longevity in Caenorhabditis elegans

Amnestic MCI is associated with a higher risk of conversion to AD [94], but those with non-amnestic MCI are a heterogenous group with a higher risk of conversion to other dementias [95]