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5.2.1 F1 generation effects (direct offspring) The F1 generation, developing during EED exposure, exhibits the most severe reproductive impairments

In randomized, placebo-controlled studies, lenabasum (20 mg/day), a cannabinoid receptor type 2 agonist, was shown to effectively improve conditions such as dermatomyositis, and a combination of CBD and aspartame effectively reduced inflammation in atopic dermatitis [127,128]

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Blots were semiquantitatively analysed by densitometry using ImageJ 2.9/1.53t (National Institutes of Health)

Under resting conditions, ASC is S-glutathionylated (notably at Cys171), a modification that impairs ASC oligomerization and prevents spontaneous inflammasome formation 67