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In line with this, a ROS/RNS-dependent regulation of IL-6 was envisaged in response to muscle exercise as shown by an impaired release of this cytokine after administration of vitamins A, C and E or inactivation of NOS by N()-nitro-l-arginine methyl ester (L-NAME) [110,111]

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These biomarkers are also used to track the efficacy of antioxidant therapies, with decreasing levels of MDA and 4-HNE indicating effective intervention [35]

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The ADOS is a semi-structured assessment administered by a trained assessor that consists of various activities that allow the observation of social and communication behaviors related to the diagnosis of ASD (5)