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The strength of correlation between maximum CMAP amplitude and our primary outcome measure, the MHFMS, suggests that in non-ambulatory patients with SMA the CMAP may be a robust surrogate outcome measure for assessing treatment interventions if the putative mechanism of effect is to enhance innervated muscle mass by reinnervation or other trophic effects on nerve or muscle

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269 BCAA uptake is dependent on the type I amino acid transporter LAT, and mutations in SLC7A5 and SLC3A2, members of the LAT family, impair BCAA uptake by T cells and inhibit the proliferation and differentiation of Th1, Th17, and CTL cells
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