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Now we get to the heart of the matter

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Mast cells as a unique hematopoietic lineage and cell system: from Paul Ehrlichs visions to precision medicine concepts

Results from animal models will inform the design of antibodies for use in humans, but only with evaluation under real-world conditions can the impact of, for example, effector functions on antibody prophylaxis or therapy be fully evaluated

doi: 10.1016/J.IJBIOMAC.2024.129651 48 El-FawalG

While these effects are beneficial in specific contexts such as treating growth hormone deficiency in children, muscle wasting conditions, or severe catabolism, they create unwanted consequences when the goal is simply fat reduction