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(2012) 130:S7782

These effects suggest involvement in transcriptional and enzymatic pathways that govern cellular defense mechanisms and metabolic homeostasis

Pickart estimated lethal dose at approximately 22,500 mg for humans (300-fold above effective doses), with animal LD50 studies in mice showing 8 mg per 25g mouse (320 mg/kg, translating to ~22,400 mg for 154 lb human)

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Beyond chemical NET inducers, XKR8 KO neutrophils also exhibited severely impaired NET formation when challenged with physiological NET activators, including the fungal organism Candida albicans and various bacterial species ( Staphylococcus aureus , Listeria monocytogenes and Escherichia coli ) (Fig