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Estrogen modulates the local renin angiotensin system via downregulation of ACE and simultaneous upregulation of ACE2, AT2R and ang (1-7) receptor expression levels [57]
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Hence, specific inhibitors targeting GLUT3 have demonstrated potential in reducing glucose uptake and glycolytic capacity [75]
IRE1 RNase activity is the most prominent activity and has two distinct signaling outcomes, XBP1 splicing and RIDD induction (Iwakoshi et al
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