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This review included both RCTs and observational studies (N-RCTs, cohort, and case-control) to assess the efficacy of various Vitamin B12 administration routes

Kwon and G

The cost differential can be substantial, with cyanocobalamin costing roughly one-tenth the price of methylcobalamin in pharmaceutical quantities

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Folate deficiency leads to the accumulation of homocysteine which is associated with an increased risk of cerebrovascular diseases, depression, and dementia, with a focus on vascular dementia and Alzheimers disease (, , )