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POR may promote lipid peroxidation by accelerating the cycling between Fe 2+ and Fe 3+ in heme [47]

Similar to studies on ICH, around 2004, researchers systematically studied the metabolism and role of hemoglobin, heme, and iron in SAH and also pointed out the predictive effect of serum ferritin content on the severity of SAH (OConnell and Watson, 2003

Therefore, the redox state is an intrinsic cellular and systemic homeostasis indicator

In fact, in a study from Denmark, there was a trend for a protective effect for the variant (Leu) allele in lung cancer cases compared to controls (296), and, similarly, other studies have found a protective effect for the Leu allele (144, 399)

10.1016/0378-4274(95)03532-x 143 Wong-EkkabutJ.XuZ.TriampoW.TangI

The documented advantages of glutathione in cellular detoxification and immune support complement astaxanthins superior membrane-protective effects and potent antioxidant properties