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Mitochondrial Oxidative Stress In addition to energy generation, the mitochondrion is also the major site of cellular ROS production (Richter et al., 2015
[DOI] [PubMed] [Google Scholar] 93.Abraham N.G., Kappas A
Although NRF2 does not directly regulate serine synthesizing enzyme genes, ATF4, a key regulator of serine synthesis, was shown to be activated by NRF2
[DOI] [PubMed] [Google Scholar] 280.Gao, B
doi: 1 10.1002/ajmg.a.37880
doi: 10.1038/s41590-023-01724-6
