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Furthermore, significant changes have been observed in the content of various proteins involved in mitophagy, mitochondrial dynamics, and mitochondrial biogenesis (Quinn et al., 2020)

That alone may be enough to act on if your goals are cosmetic rather than medical

However, very high doses taken over long periods can potentially cause nerve issues or mask other nutrient deficiencies

Existing evidence is primarily from rodent studies

A vegetarian or vegan diet can see Vitamin B12 levels drop Long-term use of antibiotics, peptic ulcer treatments and some diabetes medication can reduce levels of B2, B9, and B12