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TNF, LIGHT and IL-1 all trigger transcriptional and enzymatic activation of MLCK 135137 , although reports differ as to whether the transcriptional activation is mediated by nuclear factor-B, p38 mitogen-activated protein kinase (MAPK) or the transcription factor activator protein 1 (AP-1) 135,138140

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In a recent study in 21 patients with MAFLD, fecal microbiota transfer (FMT), administered in the duodenum via endoscopy, improved the LMR in contrast to those who received an autologous FMT

The latter displace a zinc bound water molecule necessitating the energetically much less favoured anhydride mechanism as opposed to the favoured promoted-water mechanism