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How to improve R&D productivity: The pharmaceutical industrys grand challenge

However, effective strategies for preventing or treating advanced atherosclerosis and calcification are currently lacking

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[DOI] [PMC free article] [PubMed] [Google Scholar] 17.Bertolini M, McElwee K, Gilhar A, Bulfone-Paus S, Paus R

In 2010, the first human trial using RNAi technology was conducted to evaluate the therapeutic effect of siRNA for targeting the M2 subunit of ribonucleotide reductase in patients with melanoma

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