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[Abstract] BMC Immunol
Age-Associated changes in oxidative stress and NAD+ metabolism in human tissue
Importantly, sleep disorders and circadian misalignment have been shown to further disrupt gut microbiota composition, leading to altered microbial metabolite profiles (Lin et al., 2024), impaired antioxidant production, and increased generation of ROS
Given these contrasting results, further RCTs on these drugs, particularly tramadol, are desirable to establish objective measures
doi: 10.1152/ajpcell.1992.263.6.C1181
doi: 10.1046/j.1365-313x.2003.01794.x
