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Serum levels of B12 have been shown to poorly reflect tissue deficiencies, and elevated methylmalonic acid and total homocysteine levels have been seen in the majority of patients who experience a clinical response to vitamin B12

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h , Body weight, ( i ) liver weight, and ( j ) liver-to-body weight ratios in mice treated with AAV8-GFP (n=9) or AAV8-AGXT (n=10)
