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B12 shots are generally safe

Gigure, S

Acting directly on adipose tissue without affecting insulin sensitivity or IGF-1 production

In beta-3 receptor knockout mice, AOD-9604s chronic weight and lipolysis effects were lost, showing the receptor is necessary for the sustained effect yet acute increases in energy expenditure and fat oxidation still occurred in those same knockout animals

Supplementary Materials Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request.

This is unlike fat soluble vitamins, like vitamins A, D E, and K, which will continue to get stored in the bodys fat when supplemented excessively, and can lead to side effects if over supplemented beyond the bodys needs