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Under this alternative pathway, a medical device that has received FDA marketing authorization (that is, has been approved or cleared by, or had a De Novo classification request granted by, FDA) as a Breakthrough Device, for the indication covered by the Breakthrough Device designation, will need to meet the requirements of 412.87(c)

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For this study, 67-week female C57BL/6 strain mice were purchased from Home-SPF (Beijing) Biotechnology Co., Ltd

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