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Insufficient DNA methylation may impact fertility and embryonic development 43,44 healthy ageing 45 as well as carcinogenesis through the hypomethylation of proto-oncogenes and growth factors 46

Moreover, patients with these three GRK4 variants have a better antihypertensive response to candesartan, an ARB, than those with GRK4 WT gene [166]

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doi:10.1017/s0007114520003207 Khani B, Mardanian F, Fesharaki SJ