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1996, 270 (2 Pt 1): E209-E214

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In colorectal cancer (CRC) cell lines, dusigitumab neutralized IGF-2 and induced significant tumor growth inhibition in mouse models that overexpressed IGF-2, a finding that supports evaluation of dusigitumab in CRC patients whose tumors overexpress IGF-2 [128]

The Nrf2-Keap1 pathway is another key regulator, turning on genes that drive glutathione production and detoxification

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Biomed Pharmacotherapy
