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These proteins attach to pathogens after being activated by a recognition protein such as C-reactive protein (CRP), natural IgM, or mannan-binding lectin

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Bystander activation can trigger autoreactive T cells that may target self-antigens, including those present in the thyroid gland

Polyalanine (PA), poly(alanine-co-phenylalanine), and poly(alanine-co-leucine) conjugated to PEG or poloxamer are some examples of thermosensitive copolymers

Support for this work was provided by the Intramural Research Program of the Vaccine Research Center, National Institute of Allergy and Infectious Diseases, US National Institutes of Health