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Indeed, the functional role of inhibition is not solely determined by its strength, but also by the timing relative to the excitatory drive [76, 77]

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Since damaged mitochondria are a significant source of ROS, preventing their autophagic removal may help maintain mitochondrial fitness and reduce pro-ferroptotic oxidative stress signals (109) ( Figure 5 )

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It has been suggested that only 1032% of total mitochondrial CoQ is bound to membrane proteins (50, 51)

2,15,18 Lactic acidosis is a manifestation of poor tissue perfusion and can be aggravated by inhibition of mitochondrial calcium entry leading to decreased pyruvate dehydrogenase activity.18,19 Other effects are bowel infarction and ileus.2,20-22 Pulmonary oedema23-26 (both cardiogenic and non-cardiogenic) might be caused by excessive fluid resuscitation and precapillary vasodilatation, resulting in increased transcapillary pressure
