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it is intertwined and closely linked with multiple core metabolic pathways to jointly maintain the normal physiological functions of cells

In addition, a portion of synthetic agents have been used clinically to treat various diseases, such as myocardial infarction, heart failure, diabetes, hypertension, tumors, and sepsis

Ferroptosis inducers Erastin [11], sorafenib [94] are able to suppress the expression of SLC7A11 to interfere with cystine uptake and thus affect GSH synthesis