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Int Immunol (2006) 18(12):168190

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ROS also participate in the differentiation of Treg cells [30], and mediate tumor immunosuppression through triggering SUMO-specific protease 3 (SENP3) accumulation [31]

Serum levels of selenium, zinc, copper, manganese, and iron in prostate cancer patients

The rationale for combining them is based on mechanistic complementarity (non-overlapping pathways), individual safety profiles, and clinical observations from practitioners administering the combination

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