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In the HepG2 fatty liver cell model, hypoxia-inducible factor-2alpha (HIF-2)/PPAR pathway was found to be essential for Lira to inhibit liver lipid synthesis and reduce lipid-induced hepatic steatosis [57]

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The high expression in glia cells suggests that Grx1 is deeply involved in supportive functions [136], such as, transcription factors activation in the nucleus [137,138] and protection of Complex I from oxidative damage at the mitochondria [139]

Doxorubicin induces endotheliotoxicity and mitochondrial dysfunction via ros/enos/no pathway

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