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Next, scaffolding analysis was carried out and it was found that R1 of compound 3f was substituted with 3-OCH3 and 4-OH on the A ring, and R1 of compounds 3m and 3n was substituted with 3-OCH3 and 4-OH on both the A and B rings
544 In addition, emerging targets such as IL-36 pathway inhibitors promote Treg cell proliferation by neutralizing the proinflammatory effects of IL-36, and TLR4/MyD88 small molecule inhibitors provide a new way of treating UC by modulating innate immune hyperactivation triggered by colony dysregulation
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Molecular Therapy 2011
Sekiguchi F, Domoto R, Nakashima K, Yamasoba D, Yamanishi H, Tsubota M, et al
The mitochondrial monothiol glutaredoxin S15 is essential for ironsulfur protein maturation in Arabidopsis thaliana
