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doi: 10.1177/0300060518789299 98 LarssonA

The MD Anderson algorithm intentionally adopts a stepped-care approach for VEGFi-related hypertension to reflect the unique clinical context of oncology patients, in whom VEGFi regimens may involve on-off treatment cycles and may also change rapidly based on therapeutic response or toxicity

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Heres the most crucial thing to keep in mind: Within the first 48-72 hours, the B12 shots will lead to a rapid increase of immature red blood cells (reticulocytes)

Research references 10 mcg/kg in animals, and human practice typically uses 200 to 800 mcg per day

Drop by 1 to 2 mg daily for 4 weeks