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doi:10.2147/JPR.S143500

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10.1016/j.brainresrev.2007.04.007 Brain Res

Methylfolate is required in the activation of tetrahydrobiopterin (i.e., BH4), which is a necessary cofactor for both tryptophan hydroxylase and tyrosine hydroxylase, enzymes required in the synthesis of serotonin and norepinephrine/dopamine, respectively (Figure 1)

The samples were stored at 20C until analyzed

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