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Association of thyroid stimulating hormone and coronary lipid risk factors with lipid peroxidation in hypothyroidism

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The pressure of ADT leads to AR-activating alterations in androgen levels, the AR gene, and the elaborate and diverse molecular machinery that AR needs to engage to alter transcription of its target genes

doi: 10.3390/antiox11020416

Conclusion: direct IV NAD+ has a real biological effect , although the mechanism is more complex than simple replenishment of the NAD+ pool (via metabolites)