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If you experience swelling while using AOD 9604, consider other causes

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Medeiros AI, Serezani CH, Lee SP, Peters-Golden M

Houshmand F, Barati M, Golab F, Ramezani-sefidar S, Tanbakooie S, Tabatabaei M, Amiri M, Sanadgol N (2019) Metformin-induced AMPK activation stimulates remyelination through induction of neurotrophic factors, downregulation of NogoA and recruitment of Olig2+precursor cells in the cuprizone murine model of multiple sclerosis

1 In the absence of adequate GSH concentrations, numerous oxidative and nitrosative reactive intermediates persist, including superoxide, hydroxide, peroxide, and peroxynitrite radicals, which all can lead to modification of cellular macromolecules including lipid membranes (measured in vivo by F2-isoprostanes) and DNA adduct formation (measured in vivo by 8-hydroxy-2-deoxyguanosine [8-OHdG])

So she set out looking for a more natural alternative to the histamine blockers, like Pepcid AC, that many Asian people illicitly use to combat redness