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While an approimately 200 base pair region upstream of the translational initiation site of the cytosolic isoform (3-ATG) of the murine Gpx4 gene contains binding sites for stimulating protein 1/3, nuclear factor Y and members of the SMAD family [78], regulation of Gpx4 by the oxidative stress sensing Kelch-like ECH-associated protein 1-(KEAP1)/nuclear factor-erythroid 2-related factor 2 (Nrf2) system remains strongly debated and also less likely due to the lack of related structural cis -elements in its promoter region

[DOI] [PubMed] [Google Scholar] 36.Boo S., Dagnino L

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This interaction sequesters CR3 from binding to DBD of TP53 and this sequestration or inhibition of CR3 unleashes TP53 to carry its apoptotic function

Furthermore, an inverse correlation was identified between the percentage of PS-positive erythrocytes and hemoglobin concentration