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The Abdulghani study directly compared a topical copper peptide to tretinoin and found superior tolerability with comparable or greater collagen improvements

Al-Zubaidi U, Adhikari D, Cinar O, Zhang Q-H, Yuen WS, Murphy MP, et al

Irisin ameliorates cardiac ischemia-reperfusion injury by altering gut microbiota and intestinal permeability in rats
Lactobacillus Rhamnosus GG derived extracellular vesicles modulate gut microbiota and attenuate inflammatory in DSS-induced colitis mice

While copper allergy appears rare, patch testing could be prudent for patients with a history of metal sensitivity or atopic dermatitis

Ferroptosis has attracted much attention recently in the area of neurodegeneration since the involvement of ferroptosis in Parkinsons disease (PD), a major neurodegenerative disease, has been indicated using animal models
