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For evaluation of in vivo tumor growth, a total of 6 10 5 cells (resuspended in 50 L DMEM medium and 50 L Matrigel) were subcutaneously injected into the flank of mice

24 Compared with solvent treatment, populations of control (EV) RNAi animals treated with metabolite have significantly greater fragmentation characterized by circularly shaped mitochondria, which is potentially indicative of increased mitophagic activity due to decreased mitochondrial fission and more rapid turnover of mitochondria (Figures 5a and b)

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Results are shown as percentages of the control

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