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[DOI] [PubMed] [Google Scholar] 120.OKane M., Parretti H.M., Pinkney J., Welbourn R., Hughes C.A., Mok J., Walker N., Thomas D., Devin J., Coulman K.D

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Pigment production begins in the deeper layers of the skin and naturally rises to the surface where it concentrates in dark spots

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These reactions are usually mild to moderate, appear early in treatment or after a dose increase, and often become less noticeable over time