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As indicated in Figure 4D, the expression of GFAP and Iba-1 in the brains of APP/PS1 mice was significantly upregulated compared with that in WT mice

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Importantly, small molecules or biological proteostasis regulators should aim for the enhancement and/or adaptation of protein homeostasis capacity in such a way that they prolong the time period in which cells are able to adequately handle aberrant protein species and not to continuously activate a cellular stress response, as that can be highly toxic