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As for the possible mechanism, GR-induced CLU upregulation was shown to inhibit DNA damage-induced apoptosis through mechanisms involving e.g., stabilization of Ku70 (70 kDa subunit of Ku antigen) and Bcl-2-associated X protein (Bax) interaction, which prevents its translocation to the outer mitochondrial membrane and subsequent release of cytochrome c (cyto c ) [178]

They work primarily by suppressing appetite and slowing gastric emptying

Frontiers in systems neuroscience,
