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Importantly, this proof-of-concept study showed that the relative abundance of Lactobacillus , a genus associated with weight loss 58 , was uniquely increased and Erysipelatoclostridium was distinctly decreased in mice given 5A-1MQ treatment and an LD switch compared to mice switched to LD and given vehicle treatment

Dose ranges come from allometric scaling (using a math formula to translate a mouse mg/kg dose into a human dose) and from research community use

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Elevated oxidative stress fosters the proliferation and hypertrophy of vascular smooth muscle cells, as well as collagen deposition, culminating in vascular medial thickening and constriction

doi: 10.1038/s41598-018-26882-8

GLP-1 agonists work primarily through appetite suppression and slower gastric emptying