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Moreover, novel roles of GSTs in other diseases, such as pulmonary fibrosis and neurodegenerative diseases, have been recognized in recent years, although the exact regulatory mechanisms remain to be elucidated

Although elevated iron levels may initially enhance autophagic activity, they ultimately disrupt the autophagy, thereby compromising the self-protective capabilities of autophagy [118]

References: Bennett JW, Klich M

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Further study revealed that E2-induced estrogen in breast cancer 1, as an early prototypical estrogen-responsive gene, encodes a protein that modulates downstream gene expression to promote endometriosis development (12)

This process renders harmful compounds water-soluble so they can be safely excreted by the body