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doi: 10.1016/j.alit.2017.04.013 37 OhnoI

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[47] found that exosomes from NP cells (NP-exos) could successfully induce BMSCs to differentiate into NP cells, while exosomes from BMSCs (BMSC-exos) could promote the expression of NP cell-related genes and increase ECM production, thereby achieving the effect of IVD self-repair

The lack of a single target has made DSIP harder to develop as a pharmaceutical, but the same versatility is partly why it has attracted research interest across different therapeutic areas

Endogenous Antioxidants All cells contain antioxidant systems that specifically detoxify superoxide or hydrogen peroxide or contribute to the defense against ROS (Figure 2)

Vitamin E (100 IU): Recycles glutathione, ensuring prolonged antioxidant activity