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Overall, although potential interactions exist between GPX4 and synovial inflammation, this field is still in its early stages and requires more in vivo data support

Chikara S, Nagaprashantha LD, Singhal J et al (2018) Oxidative stress and dietary phytochemicals: role in cancer chemoprevention and treatment

Higashi, T., Friedman, S

The efficacy of evexomostat in inhibiting the angiogenic proteins FGF (Fibroblast growth factors) and VEGF (Vascular endothelial growth factor) was validated in a phase I clinical trial in advanced solid tumors (NCT02743637)

The acid can break the copper bond, making both ingredients less effective