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A., Safiri, S., Tsoi, D., Adedoyin, R

In this strain, the TPI activity is just 30% compared to that of the wild type

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The crystal structure of the lectin domain of NagH in complex with GlcNAc1-2Man demonstrated that the disaccharide unit is buried inside the hydrophobic groove composed of Y819, W836, and W935, and the OH3 and OH4 of GlcNAc form hydrogen bonds with aspartic acid, D877 (Fig

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However, drug resistance against these new drugs will likely limit their efficacy in the clinic