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doi:10.3945/ajcn.2009.27462Y

Additionally, because Ipamorelin is a selective growth hormone secretagogue, it does not increase plasma levels of cortisol, the stress hormone, or adrenocorticotropic, another hormone originating in the pituitary gland

Of the 846 ligand-regulated phosphosites (categories I and II), 49 sites were equally upregulated (category I-A) and 288 sites were equally downregulated (category II-A) in both WT-IR and L973F-IR cells in response to ligand stimulation (up- or downregulation of these sites was not significantly changed between these 2 cell lines)

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Researchers propose that its role in optimizing mitochondrial function and reducing oxidative load may influence healthy aging and longevity pathways