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Parasite sizes were segmented and analyzed using the General Analysis Module of NIS-Elements 5.42.02

Curr Genet 66:719727

Fluorescent staining for casepase3/7 was done using CellEvent TM Caspase-3/7 Green Detection Reagent Kit (Thermo Fisher Scientific)

Abbreviations ALR: Aug-menter of liver regeneration ATP: Adenosine triphosphate AMPK: Amp-dependent protein kinase ALT: Alanine aminotransferase AST: Aspartate aminotransferase ARE: Antioxidant responsive element ADR: Adverse drug reaction ATDILI: Anti-tuberculosis DILI APAP: Acetaminophen AMPK/Nrf2: Adenosine 5 -monophosphate (AMP)-activated protein kinase/nuclear respiratory factor2 BCL-2: B-cell lymphoma-2 CYP3A: Cytochrome P450 3A CD1: Cyclin D1 DILI: Drug-induced liver injury ERK: Extracellular regulated protein kinases GSH: Glutathione GSH-Px: Glutathione peroxidase HSP27: Heat shock protein 27 HSP70: Heat shock protein 70 iNOS: Inductible Nitric Oxide Synthase DHM: Dihydromyricetin HO-1: Heme oxygenase-1 HILI: Herb-induced liver injury INH: Isoniazid IL-1: Interleukin-1 IL-6: Interleukin-6 JNK: C-Jun N-terminal kinase NSAIDs: LKB, liver kinase B KT: Ketoconazole Non-steroidal anti-inflammatory drugs MTX: Methotrexate MDA: Malondialdehyde NAPQI: N-acetyl-p-benzoquinoneimine NRF2: Nuclear respiratory factor2 NF-B: The master immune transcription factor nuclear factor kappa B NO: Nitric Oxide PI3K: Phosphoinositide 3-kinase PKA: Protein kinase A PCNA: Proliferating Cell Nuclear Antigen PGSs: Platycodon grandiflorum RFP: Rifampicin PCNA: Proliferating cell nuclear antigen ROS: Reactive oxygen species SOD: Superoxide dismutase SC: Schisandra chinensis TNF: Tumour necrosis factor TVX: Trovafloxacin TNF-: Tumor necrosis factor-alpha TLR4: Toll-like receptors 4 TG: Triglyceride References Chalasani NP, Maddur H, Russo MW, Wong RJ, Reddy KR