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Although the trend is consistent, the predicted PK curves did not align well with the observed data for the 2 mg and 40 mg dose groups

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Murine infection and virulence assays Virulence of WT, gsh2 mutant, and gsh2::GSH2 strains was tested in a murine inhalation model of cryptococcosis using female BALB/c mice (4 6 weeks old) from Charles River Laboratories (Ontario, Canada)

Chillon et al
