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NNMT activation can contribute to the development of fatty liver disease by modulating the NAD + metabolism

FIGURE 6 4.2.1 SAM-competitive inhibitors SAM-competitive inhibitors compete with the substrate SAM for the binding site in NNMT

NNMT plays a key role in metabolic dysfunction, and its inhibition has been shown to reverse obesity-related changes in adipose tissue. Kraus et al., Cell Metabolism How 5-Amino-1MQ Works The primary mechanism behind 5-Amino-1MQ lies in its ability to inhibit nicotinamide N-methyltransferase (NNMT) an enzyme that is often overexpressed in fat cells, cancer cells, and aging tissues

This dose can be taken daily as anything the body cannot use immediately is excreted in urine

Most experienced researchers settle on 300-500mcg as the optimal daily dose