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In stressful situations, the activation of KORs mediates dysphoric and anxiety-inducing effects, which are primarily characterized by a significant reduction in dopamine release in brain regions associated with reward

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Ultimately, this leads to activation of blood coagulation and thrombus formation, which demonstrates that LPS-induced inflammation associated with increased intestinal wall permeability may be involved in the development of atherosclerosis and thrombotic diseases (Violi et al., 2023)

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But it also supports the function of aquaporin-3, a water channel protein that naturally declines as we age

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